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HuProt™人全蛋白质组芯片
HuProt™ HuProtTM V4.0芯片上有超过2万个酿酒酵母表达, 带有GST和His标签的重组人蛋白和部分小鼠重要蛋白, 其中89%为全长蛋白,涉及约17000个人类基因和124种鼠对照蛋白。酵母蛋白具有翻译后修饰, 故也适用于PTM研究。非接触喷印 (Arrayjet Non-Contact Piezoelectric Print) 保证了样品点均匀度和复点间一致性, 分析结果更准确。
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检测时，分析物（Analyte）先与芯片孵育, 并与特定蛋白结合。分析物是血液IgG或杂交瘤培养上清时, 使用荧光标记的抗人(鼠)IgG抗体即可检出结合的IgG, 对其他分子则通过标记分析物或其抗体的方式检测，荧光扫描芯片取得数据后用于分析, 后续针对初筛得到的蛋白定制小规模芯片进行大样本验证。
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Humoral immune response to tumor-associated antigen Ubiquilin 1 (UBQLN1) and its tumor-promoting potential in lung cancer. BMC Cancer.2024 Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination
A novel enzyme-linked ligand-sorbent assay (ELLSA) to screening pulmonary tuberculosis: a retrospective cross-sectional study. Microbes Infect.2023 ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells. PLoS Negl Trop Dis. 2023 Exploration of the Hsa-miR-1587-Protein Interaction and the Inhibition to CASK. Int J Mol Sci.2021
Sodium danshensu attenuates cerebral ischemia-reperfusion injury by targeting AKT1.Front Pharmacol.2021 |
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文献题名 |
发表刊物 |
发表年份 |
研究类型 |
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Circulating autoantibody profiling identifies LIMS1 as a potential target for pathogenic autoimmunity in pathologic myopia. |
Mol Cell Proteomics |
2024 |
自身抗体鉴定 |
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High-Throughput Antigen Microarray Identifies Longitudinal Prognostic Autoantibody for Chemoimmunotherapy in Advanced Non-Small Cell Lung Cancer. |
Mol Cell Proteomics |
2024 |
肿瘤自身抗体 |
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Humoral immune response to tumor-associated antigen Ubiquilin 1 (UBQLN1) and its tumor-promoting potential in lung cancer. |
BMC Cancer |
2024 |
肿瘤自身抗体 |
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Proteome microarray identifies autoantibody biomarkers for diagnosis of hepatitis B-related hepatocellular carcinoma. |
Clin Chim Acta |
2024 |
肿瘤自身抗体 |
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A novel enzyme-linked ligand-sorbent assay (ELLSA) to screening pulmonary tuberculosis: a retrospective cross-sectional study. |
Microbes Infect |
2023 |
互作蛋白鉴定 |
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A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma. |
Cancer Cell Int |
2023 |
肿瘤自身抗体 |
|
ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells. |
PLoS Negl Trop Dis |
2023 |
互作蛋白鉴定 |
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Identification of Anti-SNRPA as a Novel Serological Biomarker for Systemic Sclerosis Diagnosis. |
J Proteome Res |
2023 |
自身抗体鉴定 |
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Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis. |
Hum Reprod |
2023 |
自身抗体鉴定 |
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Circulating tumor-associated autoantibodies as novel diagnostic biomarkers in pancreatic adenocarcinoma. |
Int J Cancer |
2023 |
肿瘤自身抗体 |
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Identification of novel serological autoantibodies in Chinese prostate cancer patients using high-throughput protein arrays. |
Cancer Immunol Immunother |
2022 |
肿瘤自身抗体 |
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Characteristics of Serum Autoantibody Repertoire and Immune Subgroup Variation of Tuberculosis-Associated Obstructive Pulmonary Disease. |
Int J Chron Obstruct Pulmon Dis |
2022 |
自身抗体鉴定 |
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Serum Biomarker Panel for Rapid Early Diagnosis of Lung Cancer. |
Curr Cancer Drug Targets |
2022 |
肿瘤自身抗体 |
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Diagnostic value of anti-Kaiso autoantibody in axial spondyloarthritis. |
Front Immunol |
2022 |
自身抗体鉴定 |
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Autoantibody signatures discovered by HuProt protein microarray to enhance the diagnosis of lung cancer. |
Clin Immunol |
2022 |
肿瘤自身抗体 |
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Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays. |
Proteomics Clin Appl |
2022 |
自身抗体鉴定 |
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Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade. |
Clin Cancer Res |
2022 |
抗体治疗监测 |
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Temporal reproducibility of IgG and IgM autoantibodies in serum from healthy women. |
Sci Rep |
2022 |
血清抗体监测 |
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Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. |
Pharmacol Res |
2022 |
药物靶点鉴定 |
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A combination of multiple autoantibodies is associated with the risk of Alzheimer's disease and cognitive impairment. |
Sci Rep |
2021 |
神经退行性疾病 |
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Sodium danshensu attenuates cerebral ischemia-reperfusion injury by targeting AKT1. |
Front Pharmacol |
2021 |
药物靶点鉴定 |
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Multiple rather than specific autoantibodies were identified in irritable bowel syndrome with HuProt™ proteome microarray. |
Front Physiol |
2021 |
自身抗体鉴定 |
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Exploration of the Hsa-miR-1587-Protein Interaction and the Inhibition to CASK. |
Int J Mol Sci |
2021 |
互作蛋白鉴定 |
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CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach. |
Neurol Neuroimmunol Neuroinflamm |
2021 |
神经类疾病自身抗体 |
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